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Applications of Enzymes in the Pharmaceutical Industry

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Applications of Enzymes in the
Pharmaceutical Industry

By: Madison, Michelle,
Nancy, Peter and Vivian

Introduction: Enzyme Lesson Recap
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Enzymes are specialized proteins that catalyze
chemical reactions.
Enzymes either combine molecules to produce
new products or break a molecule into smaller
parts.
Enzymes lower “activation energy” (amount of
energy required for reaction to occur).
Without enzymes, reactions would not occur
fast enough to sustain life.

Enzymes will only
bind with certain
substrates. At the
active site is where
the chemical
reaction occurs.

The Use of Enzymes In Medicine
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Due to the catalytic activity of enzymes they are able to
be used in a variety of ways.
The uses of important enzymes in medicine include
killing disease-causing micro-organisms, prompting
wound healing, and diagnosing certain diseases.
Pharmaceutical enzyme applications generally require
small quantities of highly purified enzymes.
Enzyme-generated products are administered to
patients in very small doses; this is in order to avoid
possible side effects.

Analytical Uses
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Enzymes can be used to detect and measure
amounts of glucose in blood.
Amount of glucose in blood and urine is an
indicator for diagnosis of diabetes.
Detected by using enzyme glucose oxidase.
Catalyses reaction between glucose and
oxygen to form gluconic acid.
Biosensor measures the produced gluconic
acid and then indicated by a colour change.

Manipulative Uses
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The goal of manipulative enzymes is to make an
enzyme that has improved properties to improve health.
Changes created through the exchange of amino acids
or modifications in the enzymes structure
Some alterations may include adding short peptide
domains. These stabilize the enzyme, and target the cell
membrane or DNA
Most common genetic alterations are with the creation
of enzymes; introducing point mutations, exchanging
protein domains, and changing the structure
Enzymes can also be manipulated by engineering
fusion proteins and enzyme hybrids

Therapeutic
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Can be administered individually or along with
other drugs and/or treatments.
Enzyme supplements for enzyme deficiencies.
Prolactazyme treats lactose intolerance.
Collagenase treats skin ulcer.
Asparaginase used to treat leukemia.
Streptokinase administered to patients
immediately after heart attacks.

Industrial Uses
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Penicillin G/V acylase and glucose isomerase
are just two of the many enzymes used in the
pharmaceuti...
Applications of Enzymes in the
Pharmaceutical Industry
By: Madison, Michelle,
Nancy, Peter and Vivian
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